How do you handle information overload?

Most of us receive too much information on a daily basis.  Just stop and think of the number of things you need to read, reply to, act on, and listen to each day.   How do you handle it?  Do you ignore some information?  Do you organize it in a way to make it easier to review and digest?  Have you found great ways to deal with the ever increasing information you are expected to process?   If yes, share some of your strategies here.

If not, then read this.  There might be some useful ways to gain control over the information you need to focus on each day.